Antidepressants work by increasing the amounts of chemicals in your brain called neurotransmitters. Neurotransmitters help carry messages between brain cells. To learn more, see Your brain’s chemical messengers.
When a brain cell needs to send a message to other brain cells, it sends out neurotransmitters. These neurotransmitters travel to the neighbouring cells. When the message has been delivered, the neurotransmitters go back inside the cell that they came from. Different kinds of antidepressants change this process in different ways.
* Tricyclic antidepressants (TCAs), such as imipramine, stop some neurotransmitters going back into the brain cells they came from. This means that the neurotransmitters are left in the gap between brain cells, and so they keep delivering the messages for longer. Tricyclic antidepressants affect several different neurotransmitters.
* Selective serotonin reuptake inhibitors (SSRIs), such as paroxetine (Seroxat), work in the same way as tricyclic antidepressants. But they only affect a neurotransmitter called serotonin.
* Venlafaxine (Efexor) is a selective serotonin and noradrenaline reuptake inhibitor (SNRI). Drugs in this group work in the same way as tricyclic antidepressants. But they work only on two neurotransmitters: serotonin and noradrenaline (which is also called norepinephrine).
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