Posts Tagged ‘mood’
Monday, March 1st, 2010
These drugs were initially used only for seizure disorders. The following anticonvulsants are now prescribed frequently in the treatment of bipolar disorder and other selected forms of depression:
* Carbamazepine (Tegretol®)
* Divalproex (Depakote®)
* Gabapentin (Neurontin®)
* Lamotrigine (Lamictal®)
* Topiramate (Topamax®)
Anticonvulsants tend to cause hyperinsulinemia (elevated insulin in the blood) and increased appetite leading to weight gain. Hyperinsulinemia also results in increased testosterone, which causes a risk to women on these medications for development of Polycystic Ovary Syndrome (POS). Polycystic ovary syndrome can cause weight gain, male pattern baldness, increased facial hair, skin tags, acne, infertility, high blood pressure, abnormal lipid levels, and heart disease.
Seizure disorder studies showed that patients taking anticonvulsants who had either a normal or below normal body mass index had the most severe weight gain.
Conventional Mood Stabilizers
Mood stabilizers were commonly used before anticonvulsants were developed for the treatment of bipolar disorder. Mood stabilizers commonly prescribed consisted primarily of the following:
* Lithium (Cibalith-S®, Duralith®,
* Ekalith®, Eskalith CR®, Lithane®,
* Lithobid®, Lithonate®, Lithotabs®)
Typically, one-third to two-thirds of the patients treated with Lithium gain weight. Of those, 25 percent gain enough weight to be classified as obese. Weight gain is dose dependent, but low doses of lithium (less than .8 mm/L) are often not therapeutic: therefore, low-dose lithium is usually not an alternative.
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Wednesday, January 20th, 2010
Nicotine exposure during the teen years may increase the risk of mood disorders such as depression, suggests a Florida State University study.
For 15 days, researchers gave adolescent rats twice daily injections of either nicotine or saline. In subsequent experiments, the rats were put in stressful and pleasurable situations, United Press International reported.
The rats exposed to nicotine showed depression- and anxiety-related behaviors, such as repetitive grooming, decreased consumption of rewards, and freezing in stressful situations, instead of trying to escape. These symptoms eased when the rats were given more nicotine or antidepressant drugs.
Adult rats exposed to the same levels of nicotine didn’t show the same depression- and anxiety-like traits, UPI reported.
The findings, published in the journal Neuropsychopharmacology, may also be true for humans, the researchers said.
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Wednesday, December 16th, 2009
Dysthymia (pronounced Dis-THIGH-me-uh) comes from the Greek roots dys, meaning “ill” or “bad”, and thymia, meaning “mind” or “emotions”. The terms dysthymia and dysthymic disorder refer to a mild, chronic state of depression.
Dysthymia or dysthymic disorder is a form of the mood disorder of depression characterized by a lack of enjoyment/pleasure in life that continues for at least two years. It differs from clinical depression in the severity of the symptoms. Dysthymia can, though not always, prevent a person from functioning, affecting sleep pattern and daily activities, it prevents full enjoyment of life.
Dysthymia may seem a paradoxical disorder in that sufferers exhibit fairly mild symptoms on a day-to-day basis, however, over a life time it can have severe effects: high rates of suicide, work impairment, and social isolation. Dysthymia typically lasts much longer than an episode of major depression, and outsiders often perceive dysthymic individuals as dour and humorless. When a major depressive episode occurs on top of dysthymia, clinicians may refer to the resultant condition as double depression.
As with other forms of depression, a number of treatments exist for dysthymia. Doctors most commonly use psychotherapy, including cognitive therapy, to help change the mind-set of the individual affected. Additionally doctors may prescribe a variety of antidepressant medications, with most individuals with dysthymia responding to Prozac and Tofranil in a positive manner. For mild or moderate depression, the American Psychiatric Association in its 2000 Treatment Guidelines for Patients with Major Depressive Disorder advises psychotherapy alone or in combination with an antidepressant as possibly appropriate.
Evidence is currently inconclusive as to whether St John’s wort extract might also prove effective in treating mild to moderate forms of depression such as dysthymia. A 2002 study involving 375 patients with mild to moderate major depression found it effective with side-effects similar to placebo . However, a 2006 study involving 150 patients with minor depressive symptoms or dysthymia found St. John’s Wort extract ineffective for the patients with dysthymia.
The term dysthymia originally referred to a sub-clinical psychotic condition, and the Greek roots of the term dysthymia (dys- (bad) and thymia) suggest the interpretation: “abnormal or disordered feelings”. Classical dysthymia refers to “feeling” something as a reality which is not a reality (for example “feeling” that one knows what others think) – or to “understanding” an underlying social dynamic which is not real. This definition of dysthymia used to cover a broad band of disorders, many of which may very likely result in anti-social behaviors. In ancient times, it was believed that the thymus “gland” was the heart of all emotions, and if one were to be depressed, said person had a “dysfunctional thymus” or “Dysthymia”. Dysthymia was not considered a specific disorder, but this name was given to any type of depression in general.
The symptoms of dysthymia are similar to major depression, but are less severe. These symptoms include:
* either poor appetite or eating too much
* sleep difficulties
* fatigue
* low self-esteem
* difficuly concentrating or making decisions
* feelings of hopelessness
A person with dysthymia may be able to function in their day-to-day life, but never feels quite right. They may report feeling like they’ve been depressed all their lives or say they feel like they are just barely managing to keep their head above water. A person with dysthymia may at some point also experience a major depressive episode. When the major depressive episode ends, they return to their previous state of chronic, low-level depression. When an episode of major depression is superimposed on dysthymia it is referred to as double depression.
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Friday, April 24th, 2009
The word perinatal refers in this case to the period during and after pregnancy. Among the mental disorders women face during this time, there are two main types: anxiety disorders and mood disorders. What’s the difference? People with anxiety disorders endure excessive fears, worries and phobias. While everyone gets nervous or has worries, for people with anxiety disorders, these feelings are exaggerated and unbearable. Anxiety disorders include generalized anxiety disorder, obsessive compulsive disorder, post-traumatic stress disorder and panic disorder.
Mood disorders, on the other hand, are described as conditions where the prevailing emotional mood is distorted or inappropriate to the circumstances. (Being so unhappy and scared as a new mom definitely feels inappropriate to the circumstance, doesn’t it?) People with mood disorders are usually in a depressive state, a manic state or both. In the depressive state, they are likely to feel hopeless, be tired all the time, and lose interest in things they used to enjoy. While most people have bouts of sadness or low self-esteem from time to time, the experience of depression is more severe and long-lasting and disrupts daily functioning. Mania is pretty much the opposite, featuring little to no fatigue, racing thoughts, reckless behavior and unrealistically high-self image. Mood disorders include depression, bipolar disorder and psychosis.
And now to perinatal mood and anxiety disorders, one of which has likely brought you to Postpartum Progress and this page. From this point forward I’m going to refer to them as PMADs. There are six main PMADs that pregnant and postpartum moms may suffer and I’m now going to provide a bit of information about each, including symptoms and risk factors.
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Saturday, April 18th, 2009
Bipolar disorder (BD) is a psychiatric diagnosis that describes a category of mood disorders defined by the presence of one or more episodes of abnormally elevated mood clinically referred to as mania or, if milder, hypomania (source: wikipedia). Bipolar, or manic-depressive disorder, is a mood disorder that causes radical emotional changes and mood swings, from manic highs to depressive lows. The majority of bipolar individuals experience alternating episodes of mania and depression.
It is known that lithium is moderately useful during all phases of bipolar illness, but it is still unclear whether this should be lithium, an antidepressant, an antipsychotic or something else, or whether the selection of the comparator agent should be based on the acute or the most recent phase, according to one article of Annals of General Psychiatry Journals published in October 2007.
There were problems in diagnosing Bipolar Disorder as it is often retrospective and carries the risk of bias and memory distortions when collecting scientific data on the treatment of Bipolar Disorder, and made its reliability and validity questionable remained. In this context, maybe the development of treatment guidelines seems to be a must issue, in order to standardize treatment choices and apply research data to everyday clinical practice, by integrating information from different sources into easily applicable and accessible algorithms, according to the article.
Konstantinos N Fountoulakis from Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece and colleagues tried to summarize the contemporary of knowledge and practice of BD’s treatment as BD is a multi-faceted illness with a complex treatment by performing a selective review of the literature.
The authors said, the literature suggests that proper treatment of BD patients needs continuous administration of an antimanic agent. We can find a comprehensive evaluation of the data concerning the various treatment modalities against the different facets of BD which was shown in table looked. Information about Lithium, Anticonvulsant, Antipsycotics, Antidepressants, and Psychotherapy and other non-pharmacological therapies including Psychoeducation interventions and the efficacy of electroconvulsive therapy (ECT) were described here in this article.
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Saturday, March 14th, 2009
Do not use Paxil if you are using pimozide (Orap), thioridazine (Mellaril), or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with Paxil. You must wait at least 14 days after stopping an MAO inhibitor before you can take Paxil. After you stop taking Paxil, you must wait at least 14 days before you start taking an MAOI.
Before taking Paxil, tell your doctor if you are allergic to any drugs, or if you have:
* liver or kidney disease;
* a bleeding or blood clotting disorder;
* seizures or epilepsy; or
* bipolar disorder (manic depression), or a history of drug abuse or suicidal thoughts.
If you have any of these conditions, you may need a dose adjustment or special tests to safely use this medication.
You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
FDA pregnancy category D. Paxil may cause heart defects or serious, life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Paxil, do not stop taking the medication without first talking to your doctor. Paxil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
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Friday, March 13th, 2009
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Paxil may cause heart defects or serious, life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Paxil, do not stop taking the medication without first talking to your doctor. Do not take Paxil together with pimozide (Orap), thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).
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